Identification of a pyroptosis-related gene prognostic signature in patients with hepatocellular carcinoma.

ABSTRACT:

Background

Pyroptosis has been recently identified as a hallmark of cancer biology; however, the potential of pyroptosis-related genes (PRGs) as prognostic markers has not been fully elucidated in hepatocellular carcinoma (HCC). The aim of this study was to develop a PRG-associated risk signature for prediction prognosis in patients with HCC.

Methods

We identified 35 PRGs from the published literature, and pyroptosis subtypes were identified through bioinformatics methods. The risk score model was established by applying least absolute shrinkage and selection operator (LASSO) Cox regression method in The Cancer Genome Atlas (TCGA) cohort and validated in International Cancer Genome Consortium (ICGC) datasets. Additionally, immune infiltration, enriched pathways, and genomic

SUBMITTER: Chen R 

PROVIDER: S-EPMC11921290 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature