Clinical and molecular characteristics of periampullary carcinoma based on pathological subtypes.

ABSTRACT:

Background

Periampullary carcinoma (PAC) is a relatively rare but highly aggressive malignancy, posing challenges to the determination of the optimal therapeutic approach. The objective of this study was to clarify the potential of histopathological typing in guiding chemotherapy selection for patients with advanced PAC and to characterize the distinct molecular features, underlying functional changes, and regulatory mechanisms associated with the different subtypes.

Methods

We conducted a retrospective analysis of clinical data from patients with advanced PAC admitted to the Oncology Department of Xijing Hospital between January 2015 and May 2022. These patients received first-line chemotherapy with either FOLFOX (folinic acid, fluorouracil, and oxaliplatin) or gemcitabine-

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11921310 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature