Amniotic fluid stem cell conditioned medium's role in Schwann cell proliferation, survival, and cellular antioxidant activity under normative and oxidative stress conditions.

ABSTRACT:

Background

Peripheral nerve injuries present a major clinical challenge due to their high morbidity and often incomplete recovery of function. While autografts remain the gold standard for nerve repair, their use is constrained by limited donor availability and donor site complications. Alternative strategies, such as allografts and tissue-engineered grafts, have been developed but are still associated with suboptimal outcomes, including chronic pain and sensory disturbances. Thus, there is a need for novel therapies that can enhance nerve regeneration. Amniotic fluid stem cell conditioned medium (AFS-CM) houses regenerative properties that may be useful in peripheral nerve injury. This study aims to assess the role of AFS-CM on Schwann cell survival and proliferation under normati

SUBMITTER: Gwam C 

PROVIDER: S-EPMC11921312 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature