Mitophagy and immune cell interaction: insights into pathogenesis and potential targets for necrotizing enterocolitis.

ABSTRACT:

Background

Neonatal necrotizing enterocolitis (NEC) is a fatal disease in early life characterized by an inflammatory response or even necrosis of the bowel wall. NEC is one of the leading causes of preterm infant mortality. The pathogenesis of NEC is intricate and involves mitochondrial damage to intestinal cells and infiltration of immune cells. However, the specific functions of mitophagy and its association with immune cells in NEC remain unclear. The aim of this study was to explore the pivotal roles of mitophagy and the immune microenvironment in NEC and their potential interactions.

Methods

Microarray data (GSE46619) associated with NEC were obtained from the Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI). Differentially expr

SUBMITTER: Jin X 

PROVIDER: S-EPMC11921342 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature