Prognostic analysis of N3 locally advanced breast cancer according to the 8th edition of AJCC clinical stage: a propensity-matched SEER analysis.

ABSTRACT:

Background

The 8th edition of the American Joint Committee on Cancer (AJCC) clinical staging-including both anatomical and prognostic staging-serves as a valuable tool for predicting the prognosis of N3 locally advanced breast cancer (LABC). This study aims to apply these criteria to analyze changes in staging and evaluate differences in survival outcomes.

Methods

Data from the Surveillance, Epidemiology, and End Results (SEER) database were used for patients with newly diagnosed N3 LABC and complete follow-up from 2010 to 2015. Patients were categorized into N3a, N3b, and N3c groups. Chi-squared tests compared differences, while univariate and multivariate Cox analyses assessed breast cancer-specific survival (BCSS) and overall survival (OS). Kaplan-Meier curves and the log

SUBMITTER: Li Q 

PROVIDER: S-EPMC11921349 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature