Complex of intratumoral mycobiome and bacteriome predicts the recurrence of laryngeal squamous cell carcinoma.

ABSTRACT: Dysbiosis of intratumoral fungal and bacterial communities is associated with poor prognosis in various cancers. However, the mycobiome characteristics in laryngeal squamous cell carcinoma (LSCC) and its correlation with recurrence have not yet been investigated. The mycobiome in 80 LSCC samples was characterized using internal transcribed spacer sequencing, encompassing both tumor tissues and their matched para-cancerous tissues. The intratumoral bacteriome was further identified using 16S rRNA sequencing. These two microbial communities were analyzed using bioinformatics and statistical methods to determine its potential correlation with LSCC recurrence. The fungal alpha diversity in tumors was higher compared with that in para-cancerous tissues (P < 0.001). A significant differen

SUBMITTER: Mao X 

PROVIDER: S-EPMC11921384 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature