Inhibition of pneumococcal growth and biofilm formation by human isolates of <i>Streptococcus mitis</i> and <i>Streptococcus oralis</i>.

ABSTRACT: In a world facing the unprecedented threat of antibiotic-resistant bacteria, targeted approaches to control colonization and prevent disease caused by common pathobionts offer a promising solution. Streptococcus pneumoniae (pneumococcus) is a leading cause of infections worldwide, affecting both children and adults despite available antimicrobials and vaccines. Colonization, which occurs in the form of a biofilm in the upper respiratory tract, is frequent and a prerequisite for disease and transmission. The use of live bacterial strains as biotherapeutics for infectious diseases is actively being explored. Here, we investigated the potential of commensal streptococci to control S. pneumoniae. Screening of over 300 human isolates led to the identification of seven strains (one

SUBMITTER: Borralho J 

PROVIDER: S-EPMC11921387 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature