Selective intra-arterial mitomycin-C infusions for treatment-refractory colorectal liver metastases.

ABSTRACT:

Background

Mitomycin-C is an older drug which has a synergistic mechanism of action with irinotecan. This study evaluated the outcomes of selective intra-arterial mitomycin-C infusions in combination with bi-weekly systemic irinotecan for treatment of liver-dominant metastatic colorectal cancer (CRC) which progressed after hepatic arterial infusion (HAI) pump chemotherapy with floxuridine and at least two lines of systemic chemotherapy.

Methods

An IRB-approved retrospective review of patients receiving at least two sessions of selective monthly mitomycin-C infusions in interventional radiology (IR) was performed. Anatomic and metabolic imaging was initially obtained at 4 weeks after the second infusion, and every 2-3 months thereafter. Response was evaluated according to Res

SUBMITTER: Sotirchos VS 

PROVIDER: S-EPMC11921435 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature