Interactive and evolutionary effect of CASZ1 gene variants on varicose veins susceptibility in South Asian Indians.

ABSTRACT:

Background

Varicose veins (VV) are spectrum of common vascular diseases having complex genetic etiology. The Castor Zinc Finger 1 (CASZ1) gene has been involved in vascular development and its variant has shown association with VV in various ethnicities, but CASZ1 susceptibility to VV risk is unexplored in the South Asian Indian population. The objective of this study was to estimate the association of the CASZ1 gene variations and VV susceptibility in the South Asian Indians, and to examine the evolutionary patterns of these variants compared to other populations.

Methodology

Population based case control analysis was conducted on all CASZ1 variants present in the Global Screening Array, including the established VV variant rs11121615 with a focus on validating and identifi

SUBMITTER: Mehra R 

PROVIDER: S-EPMC11921479 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature