Genomic alterations in Bacteroides fragilis favor adaptation in colorectal cancer microenvironment.

ABSTRACT:

Background

The occurrence and development of colorectal cancer (CRC) is an incredibly long process that involves continuous changes in the tumor microenvironment. These constant changes may ultimately result in genetic alterations and changes in the metabolic processes of some symbiotic bacteria as a way to adapt to the changing environment. Patients with CRC exhibit an altered abundance of Bacteroides fragilis (B. fragilis) as indicated by several studies. To better understand the genomic characteristics and virulence spectrum of B. fragilis strains in tumor tissues, B. fragilis strains were isolated from tumor and paracancerous tissues of CRC patients.

Methods

The isolates were identified using 16 S rRNA sequencing, morphological analysis, physiological and biochemical cha

SUBMITTER: Yang H 

PROVIDER: S-EPMC11921484 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature