Deciphering the transcriptomic landscape of systemic lupus erythematosus-associated pulmonary arterial hypertension.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multi-organ damage. Pulmonary arterial hypertension (PAH) is one of the life-threatening complications of SLE. The underlying cause of systemic lupus erythematosus-associated pulmonary arterial hypertension has not been fully comprehended. Besides the mechanisms implicated in the development of PAH, such as damage to the endothelial cells, the aberrant activation of the immune system also plays a substantial role in the pathogenesis of SLE-PAH.

Methods

In this study, peripheral blood samples from 100 patients with SLE-PAH and 95 patients of SLE without PAH (SLE-nonPAH) were obtained for RNA sequencing and comprehensive transcriptomic analysis. Pathway enrichment analysis was performed based

SUBMITTER: Li Y 

PROVIDER: S-EPMC11921494 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature