Nonlinear association of TSH with pulmonary ventilation: insights from bidirectional Mendelian randomization and cross-sectional study.

ABSTRACT:

Background

Thyroid hormones play a crucial role in numerous physiological processes, including pulmonary function. However, the relationship between thyroid function and different patterns of pulmonary ventilation remains unclear.

Methods

This study employed a bidirectional two-sample Mendelian randomization (MR) approach combined with a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) to explore the relationship between thyroid function and pulmonary ventilation indicators. We used genomic data from the ThyroidOmics Consortium and the UK Biobank to derive instrumental variables for thyroid and pulmonary functions. Adults from the NHANES 2007-2012 were included to validate the MR findings through weighted generalized linear model (GLM)

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11921497 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature