The influence of extrinsic apoptosis gene expression on immunological reconstitution of male ART-treated PLHIV.

ABSTRACT: The primary goal of antiretroviral therapy (ART) is to suppress viral replication to undetectable levels (< 50 copies/mL). Despite achieving complete viral suppression, 10-40% of individuals on ART do not adequately restore their CD4 + T-cell count, being defined as immunological non-responders (INR). Factors such as sex, age at treatment initiation, coinfections, and pre-ART CD4 + T-cell count may influence this insufficient recovery. This impairment can also result from poor production or exacerbated destruction of CD4 + T-cells, particularly through extrinsic pathway-mediated apoptosis involving Fas/FasL and caspase-3. Thus, this study aimed to evaluate the expression profile of extrinsic apoptosis pathway genes (CASP3, FAS, FASLG) in adult male HIV patients on ART. The patients were st

SUBMITTER: Lopes-Araujo HF 

PROVIDER: S-EPMC11921504 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature