The efficacy of levodopa/carbidopa/entacapone on cognitive function in moderate to advanced Parkinson's disease and its relationship with peripheral inflammatory cytokines.

ABSTRACT:

Background

Entacapone has been widely used in the treatment of moderate to advanced Parkinson's disease (PD), and its efficacy for motor symptoms has been well-known from several clinical trials and long-term clinical use. The efficacy of Levodopa/Carbidopa/Entacapone (LCE) on neuropsychological functions in moderate to advanced PD has not been validated yet, and little is known about the effect of LCE on peripheral inflammatory cytokines.

Objectives

The aim of this study was to investigate the efficacy of LCE on neuropsychological functions in moderate to advanced PD and to explore its relationship with the changes in peripheral inflammatory cytokine levels.

Methods

All patients were randomly assigned to the experimental group receiving treatment of LCE or the contro

SUBMITTER: Xu D 

PROVIDER: S-EPMC11921595 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature