Abnormalities in brain complexity in children with autism spectrum disorder: a sleeping state functional MRI study.

ABSTRACT:

Background and objective

The theory of complexity loss in neurodivergent brain is widely acknowledged. However, the findings of autism research do not seem to align well with this theory. We aim to investigate the brain complexity in children with ASD (Autism Spectrum Disorders) compared with the TD (Typical Developed) children in sleeping state.

Method

42 ASD children and 42 TD children were imaged using sleep-state functional magnetic resonance imaging (ss-fMRI), and brain complexity was analyzed by employing sample entropy (SampEn) and transfer entropy (TE). For the ASD group, we also investigated the relationship of symptom severity with SampEn and with TE.

Results

In compared with TD group, ASD group showed significant increased SampEn in the right inferior front

SUBMITTER: Fu S 

PROVIDER: S-EPMC11921608 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature