Glymphatic function decline as a mediator of core memory-related brain structures atrophy in aging.

ABSTRACT:

Background and objectives

This study aimed to elucidate the role of the glymphatic system-a crucial pathway for clearing waste in the brain-in the aging process and its contribution to cognitive decline. We specifically focused on the diffusion tensor imaging analysis along the perivascular space (ALPS) index as a noninvasive biomarker of glymphatic function.

Methods

Data were drawn from the Alzheimers Disease Neuroimaging Initiative (ADNI) database and a separate validation cohort to analyze the ALPS index in cognitively normal older adults. The relationships among the ALPS index, brain morphometry, and memory performance were examined.

Results

As a biomarker of glymphatic function, the ALPS index appeared to decline with age in both cohorts. According to the brain m

SUBMITTER: Chong S 

PROVIDER: S-EPMC11921812 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature