Association of oral anticoagulants with risk of brain haemorrhage expansion compared to no-anticoagulation.

ABSTRACT:

Background

The impact of direct oral anticoagulants (DOAC) on haematoma size after intracerebral haemorrhage (ICH) compared to no-anticoagulation is controversial and prospective data are lacking.

Methods

The investigator-initiated, multicentre, prospective RASUNOA-prime study enrolled patients with non-traumatic ICH and atrial fibrillation while on a DOAC, vitamin K antagonist (VKA) or no anticoagulation (non-OAC). Neuroimaging was reviewed centrally blinded to group allocation. Primary endpoint was haematoma expansion (≥ 6.5 ml or ≥ 33%, any new intraventricular blood or an increase in modified Graeb score by ≥ 2 points) between baseline and follow-up scan within 72 h after symptom onset.

Results

Of 1,440 patients screened, 951 patients with ICH symptom onset less t

SUBMITTER: Veltkamp R 

PROVIDER: S-EPMC11921975 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature