Ghrelin promotes neurologic recovery and neurogenesis in the chronic phase after experimental stroke.

ABSTRACT:

Background

The neuroprotective and proangiogenic potential of ghrelin in acute ischemic stroke has been demonstrated in experimental studies. However, the transferability of these results is limited as ghrelin was administered either before or very early after stroke onset and follow-up was limited to the first days after stroke. The aim of this study was therefore to close and extend this knowledge gap. To this end, we investigated the effect of ghrelin in two different translational animal models, one investigating acute and one investigating long-term structural and functional recovery after experimental stroke.

Methods

Middle cerebral artery occlusion (MCAO) or photothrombotic stroke was induced in 65 adult male Wistar rats. Eleven sham-operated animals served as control

SUBMITTER: Beuker C 

PROVIDER: S-EPMC11921976 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature