Association of high-density lipoprotein cholesterol with reduced intracranial haemorrhage and favourable functional outcome after thrombectomy for ischaemic stroke: a propensity-matched analysis.

ABSTRACT:

Background

Animal studies suggest that high-density lipoprotein cholesterol (HDL-C) attenuates reperfusion injury. We aimed to assess whether higher serum HDL-C levels modulate the risk of intracranial haemorrhage (ICH) after thrombectomy in human stroke survivors.

Methods

We included consecutive patients from our prospective anterior circulation large vessel occlusion (acLVO) registry who underwent thrombectomy between 01/2017 and 01/2023 at the tertiary stroke centre of the University Hospital Carl Gustav Carus in Dresden, Germany in a propensity score-matched analysis. We assessed the association between serum HDL-C levels and post-interventional ICH as well as 90-day functional outcome quantified by the modified Rankin Scale (mRS). For sensitivity analysis, we used multi

SUBMITTER: Sedghi A 

PROVIDER: S-EPMC11921977 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature