Click Chemistry-Based Bioconjugation of Iron Oxide Nanoparticles.

ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPIONs) exhibit unique properties for diverse biomedical applications, including drug delivery and diagnostic imaging. Actively targeted SPIONs enhance delivery to diseased sites, reducing side effects and enhancing treatment efficacy. However, the development of reproducible functionalization protocols is challenged by the erratic behavior of nanoparticles in suspensions, such as agglomeration and sedimentation. In this study, a functionalization method is developed and systematically optimized to attach the Fc-region of antibodies onto silica-coated SPIONs via click chemistry, ensuring controlled ligand orientation on the particle surface. The synthesis and successive modifications of silica-coated SPIONs with organic moieties are presented res

SUBMITTER: Asad S 

PROVIDER: S-EPMC11922026 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature