Causal associations of self-reported walking pace with respiratory diseases: A Mendelian randomization analysis.

ABSTRACT: Although studies have indicated causality between brisk walking and various diseases, the relationships between walking pace and respiratory diseases lack thorough investigation. The underlying relationships between walking pace and various respiratory diseases were examined through univariable Mendelian randomization (MR) analyses. Furthermore, we performed multivariable MR analyses to observe whether relationships between walking pace and respiratory diseases change after adjustment of body mass index (BMI). The genome-wide association study data of self-reported walking pace, BMI, and 42 respiratory diseases were retrieved from publicly available datasets. We employed the inverse-variance weighted, weighted median, and MR-Egger methods for MR analysis. Using the inverse-variance weighte

SUBMITTER: Huang C 

PROVIDER: S-EPMC11922406 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature