The Extracellular Matrix Promotes Diabetic Oral Wound Healing by Modulating the Microenvironment.

ABSTRACT: Oral wounds in diabetes mellitus (DM) often delay healing due to reduced angiogenesis and increased inflammatory response in the local microenvironment, even leading to graft necrosis and implant failure. Therefore, developing an effective program to promote healing is of great clinical value. Much of the current research is focused on promoting wound healing through surface adhesive materials that exert a pro-angiogenic, anti-inflammatory effect. However, the application of surface bonding materials in the oral cavity is very limited due to the humid and friction-prone environment. Decellularized extracellular adipose tissue (DAT) is an easily accessible and biocompatible material derived from adipose tissue. To further explore the potential of DAT, we used multi-omics to analyze its comp

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11922533 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature