Using a Functional Upper Limb Motor Task to Predict Cognitive and Functional Decline in Mild Cognitive Impairment and Alzheimer's Disease.

ABSTRACT:

Background

Predicting the rate of cognitive and functional decline over the course of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) is vital for advancing clinical care and research initiatives.

Objectives

The current study examined if a functional upper limb motor task could predict 1-year change in cognition (Mini Mental Status Examination [MMSE]) and daily function (Quick Dementia Rating System [QDRS]) from a sample of 61 cognitively intact, 35 MCI, and 32 AD subjects.

Results

Analyses adjusted for age, sex, and education showed that performance speed and variability on the motor task significantly predicted change in performance on the MMSE and QDRS over 1 year, and that these effects were small to medium in size (η² = 0.04-0.05).

Conc

SUBMITTER: Koppelmans V 

PROVIDER: S-EPMC11922660 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature