Nuclear receptor 4A1 is critical for neutrophil-dependent pulmonary immunity to <i>Klebsiella pneumoniae</i> infection.

ABSTRACT:

Introduction

Bacterial pneumonia is a burdensome, costly disease and increasingly challenging to treat due to antibiotic resistance. Complex host-pathogen interactions regulate protective immunity. Neutrophils play a central role in pulmonary bacterial immunity, and mechanistic understanding of neutrophil functions in bacterial pneumonia has potential clinical and fundamental application. Nuclear receptor 4a1 (Nr4a1), a member of the nuclear orphan receptor family, has been described to regulate inflammation and immune development in a cell type-specific manner, but its role in pulmonary host defense is not well understood.

Methods

Wild-type (WT) and Nr4a1^-/- mice, as well as bone marrow chimeric and Gr-1+ antibody depleted mice, were infected with Klebsiel

SUBMITTER: Sugitani N 

PROVIDER: S-EPMC11922696 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature