Exercise-induced adaptations in the kynurenine pathway: implications for health and disease management.

ABSTRACT:

Background

Tryptophan (TRP) metabolism through the kynurenine (KYN) pathway is influenced by inflammatory mediators, generating metabolites that regulate immune and inflammatory responses. Exercise has been proposed as a modulator of this pathway, but its role in health benefits and chronic disease management remains unclear.

Objective

This systematic review examines exercise-induced adaptations in the KYN pathway and their potential implications for health and disease management. Additionally, we identify key methodological considerations for future research.

Methods

A structured search of PubMed/Medline, Web of Science, and Scopus was conducted up to October 2024 to identify clinical trials investigating the effects of exercise training on the KYN pathway.

Result

SUBMITTER: Rangel MVDS 

PROVIDER: S-EPMC11922725 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature