A comprehensive spatio-cellular map of the human hypothalamus.

ABSTRACT: The hypothalamus is a brain region that plays a key role in coordinating fundamental biological functions¹. However, our understanding of the underlying cellular components and neurocircuitries have, until recently, emerged primarily from rodent studies^2,3. Here we combine single-nucleus sequencing of 433,369 human hypothalamic cells with spatial transcriptomics, generating a comprehensive spatio-cellular transcriptional map of the hypothalamus, the 'HYPOMAP'. Although conservation of neuronal cell types between humans and mice, as based on transcriptomic identity, is generally high, there are notable exceptions. Specifically, there are significant disparities in the identity of pro-opiomelanocortin neurons and in the expression levels of G-protein-coupled receptors b

SUBMITTER: Tadross JA 

PROVIDER: S-EPMC11922758 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature