Complete human recombination maps.

ABSTRACT: Human recombination maps are a valuable resource for association and linkage studies and crucial for many inferences of population history and natural selection. Existing maps^1-5 are based solely on cross-over (CO) recombination, omitting non-cross-overs (NCOs)-the more common form of recombination⁶-owing to the difficulty in detecting them. Using whole-genome sequence data in families, we estimate the number of NCOs transmitted from parent to offspring and derive complete, sex-specific recombination maps including both NCOs and COs. Mothers have fewer but longer NCOs than fathers, and oocytes accumulate NCOs in a non-regulated fashion with maternal age. Recombination, primarily NCO, is responsible for 1.8% (95% confidence interval: 1.3-2.3) and 11.3% (95% confidence

SUBMITTER: Palsson G 

PROVIDER: S-EPMC11922761 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature