Chromosome 1 variants associated with decreased HIV set-point viral load correlate with PRKAB2 expression changes.

ABSTRACT: A previous study investigated a genomic region on chromosome 1 associated with reduced human immunodeficiency virus type 1 (HIV) set-point viral load, implicating CHD1L as a novel HIV inhibitory factor. However, given that regulatory variants can influence expression of multiple nearby genes, further work is necessary to determine the impact of genetic variants on other genes in the region. This study evaluates the potential for genetic regulation of PRKAB2, a gene located upstream of CHD1L and encoding the β2 regulatory subunit of the AMPK complex, and for downstream impacts on HIV pathogenesis. Using genotype and gene expression data from the Gene Expression Omnibus repository and Genotype-Tissue Expression database, we observed cell-type-specific correlations betwee

SUBMITTER: Tough RH 

PROVIDER: S-EPMC11922826 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature