Comparing estimated protein excretion rate and spot urinary protein-creatinine ratio in assessing urinary protein excretion in patients with kidney disease in China: a single center study.

ABSTRACT:

Objectives

This study aimed to analyze the potential of the estimated protein excretion rate (ePER) as a substitute for the spot urinary protein-creatinine ratio (uPCR) in clinical reports for accurately assessing urinary protein excretion in China.

Methods

We included 1721 patients in the study and compared the differences in levels, correlation, bias, methodological evaluation between uPCR, ePER, and 24-h urinary protein.

Results

Significant differences (Z = -17.568, p < 0.001) were found between uPCR and 24-h urine protein levels in all cases. However, no statistically significant difference (Z = -0.652, p = 0.514) was found between ePER and 24-h urine protein. The bias analysis revealed that the negative bias rate between ePER and 24-h

SUBMITTER: Jia Y 

PROVIDER: S-EPMC11922839 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature