The relationship of miR-155 host gene polymorphism in the susceptibility of cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

miR-155 is overexpressed in many cancers, highlighting its potential as a biomarker for cancer diagnosis, treatment, and therapeutic evaluation. miR-155 is processed from the miR-155 host gene (MIR155HG). Genetic variations in MIR155HG may influence cancer susceptibility, but existing evidence is inconclusive. This study aimed to evaluate the association of MIR155HG polymorphisms with cancer risk.

Material/methods

A systematic literature search identified 15 case-control studies on three single nucleotide polymorphisms (SNPs): rs767649 (T > A), rs928883 (G > A), and rs1893650 (T > C). Meta-analysis was performed using RevMan 5.4, with odds ratios (ORs) and 95% confidence intervals (CIs) as effect measures.

Results

No significant associa

SUBMITTER: Jin G 

PROVIDER: S-EPMC11922843 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature