Levodopa-induced motor complications associated with benserazide and carbidopa in Parkinson's disease: a disproportionality analysis of the FAERS database.

ABSTRACT:

Background

Levodopa-induced motor complications are a significant concern in the treatment of Parkinson's disease (PD). Dopamine decarboxylase inhibitors (DCIs) such as benserazide (BSZ) and carbidopa (CD) are commonly used in conjunction with levodopa to manage PD symptoms. However, their association with motor complications remains unclear.

Methods

We performed a retrospective pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS) data from Q1 2004 to Q2 2024. The study included only adverse event reports (AERs) related to oral administration of drugs indicated for PD. We concentrated on motor complications, selecting two system organ classes (SOCs) associated with motor fluctuations and dyskinesia: nervous system disorders and general disorders/ad

SUBMITTER: Qiu H 

PROVIDER: S-EPMC11922873 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature