Clinical characteristics, molecular epidemiology and mechanisms of colistin heteroresistance in <i>Enterobacter cloacae</i> complex.

ABSTRACT:

Introduction

Colistin has emerged as the last resort for treating multidrug-resistant Enterobacter cloacae complex (ECC) infections. The primary purposes of this study were to demonstrate the presence of colistin heteroresistance in ECC and to further investigate their clinical characteristics, molecular epidemiology and mechanisms.

Methods

Population analysis profiles (PAP) were performed to confirm the heteroresistance phenotype. Average nucleotide identity (ANI) was determined to classify ECC species. Phylogenetic analysis based on core genome single nucleotide polymorphisms (cg-SNPs), multilocus sequence typing (MLST) and core genome MLST (cg-MLST). Risk factors and clinical outcomes of infections were analyzed through a retrospective case-control study. Potential

SUBMITTER: Wei C 

PROVIDER: S-EPMC11922889 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature