Longer-term and landmark analysis of transcatheter vs. surgical aortic-valve implantation in severe aortic stenosis: a meta-analysis.

ABSTRACT:

Background

Previous reports of longer-term outcomes of transcatheter aortic valve implantation (TAVI) focus on higher risk patients and suggest potential temporal changes.

Aims

To evaluate the longer-term and temporal performances of TAVI compared to surgical aortic valve replacement (SAVR).

Methods

Randomized controlled trials reporting outcomes with at least 1-year follow-up. The primary outcome was the composite of all-cause death or disabling stroke.

Results

We included 8 trials with 8,749 patients. TAVI was associated with a higher risk of longer-term (5-year) primary outcome compared to SAVR among higher-risk [odds ratio (OR), 1.25; 95% CI, 1.07-1.47] but not lower-risk participants [1.0 (0.77-1.29)]. However, a significant temporal interaction was detect

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11922901 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature