Antibacterial activity and mechanism of Sodium houttuyfonate against heteroresistant <i>Pseudomonas aeruginosa</i>.

ABSTRACT:

Background

Pseudomonas aeruginosa is a common gram-negative opportunistic pathogen that is now commonly treated with carbapenems, such as Meropenem. However, the increasing rate of emergence of heteroresistant strains poses a therapeutic challenge. Therefore, we examined the antibacterial activity of Sodium houttuyfonate (SH, a compound derived from Houttuynia cordata) in combination with Meropenem (MEM) against heteroresistant Pseudomonas aeruginosa and investigated the mechanism of Sodium houttuyfonate.

Methods

Heteroresistant Pseudomonas aeruginosa was used as the experimental strain for the study and the combined action activity of the two drugs was inves-tigated by determining the Minimum Inhibitory Concentration (MIC), Fractional Inhibitory

SUBMITTER: Li Z 

PROVIDER: S-EPMC11922930 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature