Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients.

ABSTRACT:

Introduction

Regulatory T cells (Tregs) play a crucial role in maintaining immune tolerance by suppressing immune responses against pathogens. The fluctuation of Treg proportions in COVID-19 remains a topic of debate, and the mechanisms triggering Treg activation in COVID-19 are still unclear. Understanding these issues is essential for better managing immune responses in COVID-19 patients.

Methods

We collected a cohort of COVID-19 patients with varying disease severity and stage to explore the transcriptomic and functional traits of Tregs in these individuals. Using transcriptomic analysis, we evaluated the proportion and functionality of different Treg subsets, specifically HLA_DR⁺ Tregs, across different stages of COVID-19 patients.

Results

Our analysis

SUBMITTER: Wen Y 

PROVIDER: S-EPMC11922936 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature