Exposing the cellular situation: findings from single cell RNA sequencing in breast cancer.

ABSTRACT:

Background

Breast Cancer (BC) ranks among the top three most prevalent cancers globally and stands as the principal contributor to cancer-related fatalities among women. In spite of the substantial occurrence rate of BC, the early stage of this disease is generally regarded as curable. However, intra-tumor heterogeneity presents a formidable obstacle to the success of effective treatment.

Method

In this research, single cell RNA sequencing was utilized to dissect the tumor microenvironment within BC. Slingshot, CytoTRACE and Monocle 2 were applied to illustrate the differentiation process of each subpopulation in the pseudotime sequence. To comprehensively comprehend the tumor cells (TCs) in BC, an analysis of upstream transcription factors was carried out via pySCENIC, whil

SUBMITTER: Ni G 

PROVIDER: S-EPMC11922942 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature