The transcription factor Nrf2 links Th2-mediated experimental allergy to food preservatives.

ABSTRACT:

Introduction

Immune-mediated adverse reactions to food allergens are rising at a striking rate, for reasons that are not completely understood. Our previous studies suggest that the stress-activated transcription factor Nrf2 (Nuclear factor erythroid 2 -related factor) promotes Th2 differentiation, while inhibiting Th1 differentiation.

Methods

In the present studies, we investigated the effect of Nrf2 activation on sensitization and anaphylaxis in response to food allergen in BALB/c mice. Specifically, we determined the effect of the Nrf2 activator and common food preservative tBHQ (tert-butylhydroquinone) on immune response to food allergen in Balb/c mice and SCID mice that received either wild-type or Nrf2-deficient CD4 T cells.

Results

Our results demonstrat

SUBMITTER: Jin Y 

PROVIDER: S-EPMC11922944 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature