Effect of high-intensity laser therapy and photobiomodulation therapy on oral lichen planus-a systematic review and meta-analysis.

ABSTRACT: This study evaluates the efficacy and safety of High-Intensity Laser Therapy (HILT) and Photobiomodulation (PBM) in treating Oral Lichen Planus (OLP), and explores optimal PBM parameter settings. A search of PubMed, Embase, Cochrane Library, Web of Science, CNKI, and SinoMed was conducted for randomized controlled trials (RCTs) on laser therapy for OLP up to October 30, 2024. Study quality was assessed using the Cochrane risk of bias tool and the Jadad score. Eighteen studies were identified, with 16 involving 742 participants included in the meta-analysis. Eleven studies compared PBM with topical corticosteroids (TCS), and five compared HILT with TCS. HILT provided superior pain relief compared to TCS (SMD = -0.51, 95% CI [-0.79,-0.23]), while PBM showed comparable outcomes (SMD = -0.41,

SUBMITTER: Liu P 

PROVIDER: S-EPMC11922975 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature