Identification of distinct fatigue trajectories in patients with nasopharyngeal carcinoma undergoing radiotherapy: an observational longitudinal study.

ABSTRACT:

Purpose

To investigate the fatigue trajectory types and various influencing factors during intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).

Methods

Longitudinal data of cancer-related fatigue from 182 participants with NPC were assessed at baseline (T0) and weekly (T1-T7) during radiotherapy via the revised Piper Fatigue Scale. Patient-generated data from the Subjective Global Assessment (PG-SGA) and the Hospital Anxiety and Depression Scale were collected at baseline. Latent growth curve models (LGCM) and latent class growth models (LCGM) were used to explore fatigue trajectories and heterogeneity among fatigue trajectories, respectively. The influencing factors of different trajectories were assessed via multivariate logistic regress

SUBMITTER: Wu J 

PROVIDER: S-EPMC11923017 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature