Oral administration of antimicrobial peptide MPX can effectively regulate LPS-mediated testicular oxidative stress and blood‒testis barrier damage.

ABSTRACT: Oxidative stress and disruption of blood‒testis barrier permeability are considered key factors in the pathogenesis of testicular inflammation, degeneration, and functional impairment, which play crucial roles in male infertility. Antimicrobial peptides (AMPs) are internationally recognized as some of the most promising alternatives to antibiotics. However, the molecular mechanisms by which AMPs regulate oxidative stress and the blood‒testis barrier in the testis are still poorly understood. In this study, we orally administered 0.5 mg/kg antimicrobial peptide MPX (MPX) to mice for 20 and 40 days and evaluated its effects on Lipopolysaccharide LPS-induced testicular oxidative stress and blood‒testis barrier repair, and elucidateed the pharmacokinetics of MPX in mice. The experiment was div

SUBMITTER: Zhu C 

PROVIDER: S-EPMC11923060 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature