Metabolic phenotype of bovine blood-derived neutrophils is altered in milk.

ABSTRACT: In a healthy udder, immune cells from the peripheral bloodstream migrate into mammary tissue in low numbers to provide baseline immune surveillance, without triggering inflammation. In bovine intramammary inflammation, on the other hand, high amounts of leukocytes are recruited, causing severe inflammation. We were interested in leukocyte subpopulations and functional differences between blood- and milk-derived neutrophils from healthy and inflamed udder quarters. In this context, we found a distinct leukocyte subpopulation profile dependent on the health status of mammary gland quarters, with a predominant T cells population in heathy mammary gland quarters and a shift to macrophages and granulocytes in inflammation. Further, we detected divergent expression of major histocompatibility co

SUBMITTER: Duda HC 

PROVIDER: S-EPMC11923088 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature