Antimicrobial effect of blue light on antibiotic-sensitive and drug-resistant Escherichia coli: a novel isotropic optical fibre.

ABSTRACT: Background. Orthopaedic oncological pelvic reconstructions have an elevated risk of infection with Gram-negative bacteria. This study evaluates the bactericidal ability of a novel antimicrobial blue light (ABL)-emitting optical fibre on antibiotic-sensitive Escherichi coli (AS-Ec) and ESBL-producing E. coli (ESBL-Ec). Methods. Time-to-kill assays used a 10 ml NaCl solution with a starting inoculum of 1×10⁵ c.f.u. ml^-1 for AS-Ec or ESBL-Ec; assays were repeated at least three times per strain. Experimental tubes had either one optical fibre [20.1 mW mm^-1; low power (LP)] or two optical fibres [40.3 mW mm^-1; high power (HP)], which delivered five wavelengths of ABL over 60 min. Control tubes had no optical fibres. Fifty 

SUBMITTER: Goh MH 

PROVIDER: S-EPMC11923094 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature