Sleep deprivation impairs neurovascular coupling and cerebral vasomotor reactivity.

ABSTRACT: Sleep deficiency increases the risk of cerebrovascular diseases. However, the effects of sleep deprivation (SD) on cerebral blood flow have been poorly studied. We examined the effect of 24-h of SD on the resting posterior cerebral artery (PCA) and middle cerebral artery (MCA) flow velocities (FV), the visually evoked FV response in the PCA (neurovascular coupling), and the hypercapnia-induced FV response in the MCA (cerebral vasoreactivity). Visual evoked potential (VEP) and transcranial Doppler examinations were performed in 25 healthy adults before and after 24-h of SD. Cerebral vasoreactivity was measured by breath-holding test in left and right MCA. The visually evoked FV response was evaluated in left and right PCA. There was a tendency for increased resting mean FV in PCA (p = 0.08)

SUBMITTER: Rab-Babel KS 

PROVIDER: S-EPMC11923101 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature