Multidrug resistance in group B <i>Streptococcus</i> causing urinary tract infection exposes an erythromycin-driven protective effect against oxidative stress.

ABSTRACT: Multidrug resistance has been reported in group B Streptococcus (GBS) from various origins, but rates among urinary tract infection (UTI) isolates are largely unknown. Erythromycin, a second-line antibiotic for GBS for which high rates of resistance have been reported, was recently shown to support the resistance of Staphylococcus to oxidative stress. To survey multidrug-resistant (MDR) GBS from UTI and to investigate the effect of erythromycin exposure on the bacteria's ability to resist oxidative stress, we determined the antibacterial activity of 18 antibiotics against 292 GBS UTI isolates by disc diffusion and used in vitro growth assays of MDR GBS exposed to erythromycin to examine relative resistance to oxidative stress in the form of H₂O₂.

SUBMITTER: Desai D 

PROVIDER: S-EPMC11923109 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature