Neurobiology-based cognitive biotypes using multi-scale intrinsic connectivity networks in psychotic disorders.

ABSTRACT: Understanding neurobiology and developing effective interventions for cognitive dysfunction in psychotic disorders remain elusive. Insufficient knowledge about the biological heterogeneity of cognitive dysfunction hinders progress. We aimed to identify subgroups of patients with psychosis and distinct patterns of functional brain alterations related to cognition (cognitive biotypes). We analyzed B-SNIP consortium data (2 270 participants including participants with psychotic disorders, relatives, and controls, 55% females). We used reference-informed independent component analysis with the standardized and fully automated framework NeuroMark and the 100k multi-scale intrinsic connectivity networks (ICN) template to obtain subject-specific ICNs and whole-brain functional network connectivit

SUBMITTER: Andres-Camazon P 

PROVIDER: S-EPMC11923125 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature