Comprehensive analysis of senescence-related genes identifies prognostic clusters with distinct characteristics in glioma.

ABSTRACT: Cellular senescence, defined as a state of permanent arrest in cell growth, is regarded as a crucial tumor suppression mechanism. However, accumulating scientific evidence suggests that senescent cells play a detrimental role in the progression of cancer. Unfortunately, the current lack of reliable markers that specifically reflect the level of senescence in cancer greatly hinders our in-depth understanding of this important biological foundation. Therefore, the search for more specific and reliable markers to reveal the specific role of senescent cells in cancer progression is particularly urgent and important. To uncover the role of senescence in gliomas, we collected senescence-related genes for integrated analysis. Consensus clustering was used to subtype gliomas based on the senescenc

SUBMITTER: Wei W 

PROVIDER: S-EPMC11923138 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature