Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion.

ABSTRACT: Striatonigral neurons, traditionally known for promoting locomotion, comprise diverse subtypes with distinct transcriptomic profiles. However, their specific contributions to locomotor regulation remain incompletely understood. Using the genetic markers Kremen1 and Calb1, we demonstrate in mouse models that Kremen1⁺ and Calb1⁺ striatonigral neurons exerted opposing effects on locomotion. Kremen1⁺ neurons displayed delayed activation at locomotion onset but exhibited increasing activity during locomotion offset. In contrast, Calb1⁺ neurons showed early activation at locomotion onset and decreasing activity during locomotion offset. Optogenetic activation of Kremen1⁺ neurons suppressed ongoing locomotion, whereas activation of Calb1

SUBMITTER: Dong J 

PROVIDER: S-EPMC11923167 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature