Bidirectional relationship between platelet count and skin cancer: tumor drug resistance mechanisms.

ABSTRACT:

Background

Platelets (PLT) play a crucial role in tumor progression, including tumor growth, metastasis, and immune evasion. However, the relationship between PLT count and specific skin cancer subtypes, particularly melanoma skin cancer (MSC) and non-melanoma skin cancer (NMSC), remains poorly understood. Clarifying this association could identify potential biomarkers and therapeutic targets for personalized treatments.

Methods

We applied bidirectional Mendelian randomization (MR) to investigate the causal relationship between PLT count and skin cancer risk, focusing on MSC and NMSC. Genetic variants associated with PLT and skin cancer served as instrumental variables for causal inference. Nine MR analysis methods, with inverse-variance weighted (IVW) as the primary method,

SUBMITTER: Guo C 

PROVIDER: S-EPMC11923316 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature