Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI.

ABSTRACT:

Background

The cingulum bundle is a brain white matter fasciculus associated with the cingulate gyrus. It connects areas from the temporal to the frontal lobe. It is composed of fibers with different terminations, lengths, and structural properties, related to specific brain functions. We aimed to automatically reconstruct this fasciculus in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) and to assess whether trajectories have different microstructural properties in relation to dementia progression.

Methods

Multi-shell high angular resolution diffusion imaging-HARDI image datasets from the "Alzheimer's Disease Neuroimaging Initiative"-ADNI repository of 10 AD, 18 MCI, and 21 cognitive normal (CN) subjects were used to reconstruct three subdivisions

SUBMITTER: Ricchi M 

PROVIDER: S-EPMC11923340 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature