Relationships between hypometabolism and both β-amyloid and tau PET in corticobasal syndrome.

ABSTRACT:

Introduction

Alzheimer's disease (AD) pathology causes corticobasal syndrome (CBS) in 21%-50% of patients. Studies have assessed hypometabolism in CBS according to β-amyloid (A) positron emission tomography (PET), but the understanding of the association of both AD-tau (T) and A with hypometabolism is incomplete.

Methods

Thirty-three CBS patients and 45 controls underwent fluorodeoxyglucose (FDG), flortaucipir, and Pittsburgh compound-B PET and were classified as A± and T±. FDG-PET uptake was extracted for 12 regions-of-interest in dominant (most affected) and non-dominant hemispheres and compared across A/T groups.

Results

A+T+ patients had greater hypometabolism in temporo-parieto-occipital cortices than A+T- and A-T- groups, with no differences observed between the

SUBMITTER: Ghirelli A 

PROVIDER: S-EPMC11923383 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature